ASCO Prostate Cancer Symposium 2007:15 abstracts with comments

1 = number of abstract – I’ll ask to have CRP added to my monthly bloodtest 2 – I’ll ask to have LDH added to my monthly bloodtest 3 and 4 – Taxotere (docetaxel) + estramustine (3x280 mg/day) better than Taxotere alone 5 – same as 3 and 4, but 3x140 mg/day estramustine equally effective as 3x280 mg, and less toxic 6 – Thalidomide + bevacizumab (Avastin) + Taxotere: works! 7 – Taxotere + Carboplatin works after Taxotere alone stopped working 8 – weekly Taxotere + capecitabine (Xeloda + oral drug) is effective and well-tolerated 9 – Carboplatin + Avastin + Xeloda worked in one patient who did not respond to Taxotere alone 10 – Satraplatin + prednisone is barely better than placebo + prednisone: “at 12 mos, 16% (S+P) and 7% (P) had not progressed” 11 – Decadron (dexamethasone) has synenergy with Taxotere, at least in the Petri dish. I don’t take daily prednisone while on chemo, but 2x0.5 mg Decadron. Should I take more? 12 – biweekly Taxotere + 800 mg Celebrex/day works 13 – some patients, not responding to Taxotere, will respond to four estradiol patches – with comments by Dr. Charles Myers (3/3/07) 14 – 8 of 74 patients on Taxotere + estramustine had a PSA ‘flare-up’; did not impact survival 13, 14 & 15: androgen receptor and androgens continue to play a role after patients become hormonerefractory!